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A complete of three % of active substance is excreted in urine as unchanged active compound. Tapentadol is Moreover metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and also to hydroxy tapentadol (2 %) by CYP2D6, which might be even further metabolised by conjugation. Therefore, Energetic compound metabolism mediated by cytochrome